are protein scaffold organs a viable transplant optino

#Are protein scaffold organs a viable transplant optino skin
#Are protein scaffold organs a viable transplant optino full
#Are protein scaffold organs a viable transplant optino portable

The scaffold was treated with endothelial and epithelial cells to achieve the cell populations found in native kidneys (1). Decellularized tissue consists of a scaffold of collagen and other structural compounds without live cells (2). ECM was obtained and made into a whole-organ scaffold by decellularization of kidney tissue with detergent (1). In their study, published in Nature Medicine, the ECM of the rat kidney was used to create the scaffold for the bioengineered kidney tissue (1). They have previously worked on creating extracellular matrix (ECM) scaffolds for hearts and lungs (1, 2). Ott’s team is working to create autologous kidney tissue- tissue derived from the patient into whom it will be implanted. Such scaffolds allow more effective cultivation of biocompatible cells with appropriate structure and function (1). Previous attempts to bioengineer human tissue have included the successful use of biocompatible matrices and cells from the patient to develop urinary tract tissue to improve bladder function.

#Are protein scaffold organs a viable transplant optino portable

These have included portable or implantable devices that have improved the livesof patients unable to receive timely transplants (1). Previous successes in increasing renal function have involved renal-assist devices with various strategies of hemofiltration and hemodialysis. Between five and 10 percent of those on the kidney transplant waiting list die before receiving a transplant, and around 40 percent of those who receive a transplant will die or require another transplant within 10 years (1).ĭevelopments in bioengineering may help to provide better functioning and more readily available kidneys to those with renal failure. Approximately 100,000 people in the United States await kidney transplants, but only 18,000 or so will receive a transplant in a given year (1). The need for kidneys in patients with end-stage renal disease is a major example of the organ shortage problem. A team at Massachusetts General Hospital led by Harald Ott has successfully regenerated functional rat kidneys from decellularized extracellular matrices repopulated with native-like kidney cells. Recent attempts to address shortages have focused on creating all or part of the needed organs to make them more readily available to patients in need of transplant. The general shortage of organs for organ transplant is of great concern in the medical community. just the nature of the beast.Sprague-Dawley rats like this one were used to test the viability of regenerated kidneys Still, pre-clinical has to have some hype. In the extreme, it's the kind of technology that would seem NECESSARY for any dream of a 'battlefield robot doctor' that does more than drag you to cover. Frankly, in Iraq or Afghanistan, I'd be more worried about TBI or outright catastrophic amputation.Įven if this only works half as well as advertised, it would be a huge leap on harvesting skin, separating, culturing, incubating. As you say, 'battlefield' is a bad joke, but that also assumes the current battles we're in.

#Are protein scaffold organs a viable transplant optino full

If they can replace the deep layers of the skin, this is a major progress.įrom what I've read elsewhere, they're able to prepare the full range of the dermis, once the area is debraded. If it's superficial layers only, this is small step big hype. What would be interesting is to know the kind of burn injuries that can be adressed by this technic. Pre-clinical is very good! Too bad the hype about doing this on battlefield. If I ever get a big burn, I want stem-cell-spray with super cat-powered cells. We were glad that we had denied the vet, and not just because of the saved money. I expect that dead strip was used as a scaffold by the skin-regenerating cells. If I were interested in pursuing this field, that's where I would start. One day a huge wound, the next week healed, the next week gone without a trace. I was shocked at the effectiveness of cat-skin healing compared to ours. The strip came back to life and it all just put itself back together! Even before the fur grew back there was no sign of the wound. That 6mm strip held the sides together and the two holes closed up. With antibiotics from the vet and a little Zithromax thrown in, it just healed right up. The vet gave a quote of $800, but we told her that it wasn't going to happen that way.

#Are protein scaffold organs a viable transplant optino skin

There was a thin, say 6mm wide, strip of dead skin holding together the sides of a 6cm bloody, gory wound. My cat meowed plaintively for a couple days then revealed that she had a HUGE abcess near her anus. I want to throw out an experience I had as I think it relates.